Retooling Pap test to spot more kinds of cancer


WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.


Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.


How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.


In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.


This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.


"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.


But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.


The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.


"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.


"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.


But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.


More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.


Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.


The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.


So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.


The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.


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Wall Street slightly higher on China data; S&P near resistance level

NEW YORK (Reuters) - U.S. stocks inched higher on Thursday, helped by stronger-than-expected exports in China, the world's second-biggest economy, but gains were capped as the S&P 500 hovered near a 5-year high.


Financial and telecommunications stocks were the day's top gainers, while the material sector was the biggest drag. The S&P 500 material sector index <.gspm> was off 0.3 percent. The financial sector index <.gspf> rose 0.6 percent and the telecom sector <.gspl> was up 0.5 percent.


The benchmark Standard & Poor's 500 index was near a five-year closing high of 1,466.47. On Friday, the index had ended at the highest close since December 2007.


"The market is technically right at the level of resistance, near 1,465-1,467. A solid breakthrough above the level would be the start of a next leg higher, but it looks like it is going to be difficult to break above that level for now," said Randy Frederick, managing director of active trading and derivatives at Charles Schwab. He cited concerns about the earnings season and upcoming debt ceiling talks.


The Dow Jones industrial average <.dji> was up 9.84 points, or 0.07 percent, at 13,400.35. The Standard & Poor's 500 Index <.spx> was up 2.55 points, or 0.17 percent, at 1,463.57. The Nasdaq Composite Index <.ixic> was down 2.01 points, or 0.06 percent, at 3,103.80.


In company news, shares of upscale jeweler Tiffany dropped 3.6 percent to $60.98 after it said earnings for the year through January 31 will be at the lower end of its forecast.


U.S.-traded Nokia shares jumped 17.3 percent to $4.40 after the Finnish handset maker said its fourth-quarter results were better than expected and that the mobile phone business achieved underlying profitability.


Herbalife Ltd stepped up its defense against activist investor Bill Ackman, stressing it was a legitimate company with a mission to improve nutrition and help public health. The stock was up 1.4 percent to $40.47.


Data showed China's export growth rebounded sharply to a seven-month high in December, a strong finish to the year after seven straight quarters of slowdown, even as demand from Europe and the United States remained subdued.


In the U.S., claims for unemployment benefits rose last week, though seasonal volatility made it difficult to get a clear picture of the labor market's health.


Also, U.S. wholesale inventories rose more than expected in November and sales rose by the most in more than 1-1/2 years. The market's reaction to both reports was muted.


(Reporting By Angela Moon; Editing by Nick Zieminski)



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Scotland Yard Officer Found Guilty in Phone Hacking Scandal







LONDON (AP) — A top British counterterrorism detective was found guilty Thursday of trying to sell information to one of Rupert Murdoch's tabloids, becoming the first person convicted on charges related to Britain's phone-hacking scandal since a police investigation was reopened in early 2011.




Detective Chief Inspector April Casburn was charged with misconduct for phoning the News of the World tabloid and offering to pass on information about whether London's police force would reopen its stalled phone-hacking investigation.


Prosecutors said the tabloid did not print a story based on her call and no money changed hands but she had committed a "gross breach" of the public trust by offering to sell the information.


Casburn, 53, also was accused of trying to ruin the phone-hacking inquiry — which centered on Murdoch journalists at the now-defunct News of the World — by leaking information to the press.


A key witness testified that Casburn wanted to torpedo the hacking inquiry because she feared it would drain resources from the fight against terrorism. The witness said she also was upset about the purported pressure being put on prosecutors by John Prescott, a deputy prime minister under Tony Blair who had been a hacking victim.


Prosecution lawyer Greg McGill said Casburn was guilty of a "very serious offense."


The Metropolitan Police said in a statement that selling confidential information to journalists for personal gain would not be tolerated and that Casburn had "abused" her police position.


"Casburn proactively approached the News of the World, the very newspaper being investigated, to make money," the police statement said. "She betrayed the service and let down her colleagues."


The statement said vital information on the Casburn case was given to police by the Management and Standards Committee at Murdoch's News Corp.


Casburn, who managed the Metropolitan Police terrorist financing investigation unit, had admitted contacting the newspaper but denied that she offered confidential information or had sought payment.


Jurors at Southwark Crown Court found her guilty of one count of misconduct. She will be sentenced later this month.


Britain's long-running phone-hacking scandal has led to dozens of arrests and to criminal charges against prominent journalists, including Prime Minister David Cameron's former communications chief. Other police officers and civil servants have also been questioned about possible wrongdoing.


The phone hacking scandal has involved allegations of illegal snooping on celebrities, crime victims, politicians and others. Media mogul Murdoch closed the News of the World tabloid in July 2011 after many of its misdeeds were exposed. His media company has also paid out millions to numerous victims to avoid lengthy and expensive trials.


Tim Wood, the News of the World news editor who took Casburn's call, told the court that the detective expressed concern that counterterrorism resources were being diverted to the phone-hacking investigation. Wood also said Casburn complained of interference from Prescott, a prominent hacking victim and a vocal Murdoch critic.


"The one thing that stands out in my mind is the fact that she kept going on about Lord Prescott," Wood said. "Her saying that he was pressing for them to put charges on the News of the World, and she was saying that she felt it was wrong that he was interfering in the scandal, so to speak, and she resented that."


Casburn has been suspended with pay, the force said.


A News of the World reporter and a private investigator were jailed in 2007 for hacking into the voicemails of royal aides. But the newspaper denied there was a wider problem and the police investigation was closed.


Police reopened the investigation in early 2011 as new evidence emerged about the scale of the law-breaking.


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Is BlackBerry back? Strong early BlackBerry 10 demand could signal RIM comeback






After hitting a rough patch that seemed to last for most of 2012, Research In Motion (RIMM) may finally see the light at the end of the tunnel. RIM plans to unveil the finished version of its next-generation BlackBerry 10 platform at a press conference on January 30th, and at least one new smartphone is expected to be revealed during the event. Generating interest in BlackBerry 10 within the crowded global smartphone market will be no easy task for the struggling vendor, but if demand at top Canadian Rogers is any indication, RIM is off to a promising start.


[More from BGR: ‘Apple is done’ and Surface tablet is cool, according to teens]






In mid-December, Rogers began taking reservations for RIM’s first BlackBerry 10-powered handset. The carrier offered almost no information about the BlackBerry smartphone, which has not yet been announced, but asked subscribers interested in purchasing the device to register on the company’s website.


[More from BGR: iPhone 5 now available with unlimited service, no contract on Walmart’s $ 45 Straight Talk plan]


BGR approached Rogers on Thursday to see how subscriber response has been thus far.


“While we can’t release the total number of reservations we have received for the BlackBerry 10 all-touch device, we can say that customer interest is definitely strong and reservations continue daily,” a RIM spokesperson told BGR via email.


The strong response from Rogers subscribers despite being provided only with the knowledge that the device will feature an all-touch form factor and will run the BlackBerry 10 OS is a good sign for RIM.


The vendor has a number of difficult challenges ahead, and convincing current BlackBerry users to upgrade en masse is near the top of the list. Strong early demand at Rogers for RIM’s first BlackBerry 10 handset is clearly a positive sign in this regard, as most early reservations likely came from current BlackBerry subscribers.


This article was originally published on BGR.com


Wireless News Headlines – Yahoo! News




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Chasing the Saturdays: First Look at the British Girl Group's U.S. Reality Show



From the Beatles in the '60s to the Spice Girls in the '90s and One Direction these days, American music fans have a long-running infatuation with British singing groups.

Now: meet The Saturdays!

The pop quintet – Rochelle Humes, Frankie Sandford, Mollie King, Vanessa White and Una Healy, who's Irish – are bringing their vivacious music and sexy dance moves to the U.S., and they're getting a boost from E!

Chasing the Saturdays, a new reality show on the network premiering Jan. 20, will follow the group's attempt to break into the U.S. market after their success at home.

"It's been our dream as a band since day one to actually come to America and try and break it," says Vanessa, the youngest member of the group, in a first look their series.

"It's a little bit like starting over for us," Frankie says.

"It's scary," adds Rochelle, "and a little bit daunting."

Their first U.S. single, "What About Us," featuring Sean Paul, is out now. The video is due out on Friday.

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Flu season has Boston declaring health emergency


BOSTON (AP) — Massachusetts public health officials are reporting 18 flu-related deaths in the state already this season, and Boston has declared a public health emergency.


A spokeswoman for Mayor Thomas Menino says the city is working with health care centers to offer free flu vaccines and also hopes to set up public locations where people can go for vaccinations. The city is reporting four flu-related deaths.


There have been about 700 confirmed cases of the flu in Boston so far this season, about 10 times more than in the same period last year.


The Massachusetts Department of Public Health says the state is one of many reporting above average flu hospitalization rates. The Centers for Disease Control and Prevention has warned of a harsh flu season, which usually peaks in midwinter.


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Wall Street gains as earnings flow in; Alcoa up


NEW YORK (AP) — Stocks rose on Wall Street Wednesday after U.S. corporate earnings reports got off to a good start.


The Dow Jones industrial average rose 86 points to 13,415 as of noon EST. The Dow is coming off of two days of losses.


The Standard & Poor's 500 index gained six points to 1,463 and the Nasdaq composite rose 17 points to 3,109.


Stocks, having rallied after a last-minute resolution stopped the U.S. going from over the "fiscal cliff," are facing their first challenge of the year as companies start to report their earnings for the fourth quarter of 2012. Throughout last year, analysts had cut their outlook for earnings growth in the period and now expect them to rise by 3.21 percent, according to data from S&P Capital IQ.


"Maybe earnings expectations were a little too low," said Ryan Detrick, a strategist at Schaeffer's Investment Research. "You don't need to have great earnings, you just need to beat those expectations" for stocks to rally, Detrick said.


Alcoa predicted rising demand for aluminum this year as the aerospace industry gains strength. Late Tuesday the company reported fourth-quarter revenue that beat analysts' estimates. Investors pay close attention to Alcoa's results and forecasts because the aluminum it makes is used in so many industries including construction and manufacturing.


Alcoa's stock rose 8 cents to $9.18.


Consumer products maker Helen of Troy, whose brands include Dr. Scholl's, Vicks and Fabreze, rose 89 cents to $34.42 after reporting a 15 percent increase in net income. Agricultural products giant Monsanto gained 84 cents to $99.34 after it said that its profit nearly tripled in the first fiscal quarter as sales of its biotech corn seeds expanded in Latin America.


The yield on the 10-year Treasury note was unchanged at 1.87 percent.


Among other stocks making big moves:


— Wireless network operator Clearwire jumped 22 cents to $3.14 after Dish network made an unsolicited offer to buy the company, which has already agreed to sell itself to Sprint. Dish rose $1.17 to $37.14 and Sprint fell 8 cents to $5.89.


— Online education company Apollo Group plunged 10 percent after reporting a sharp decline in fall-term student sign-ups at the University of Phoenix. The stock fell $2.04 to $18.88.


— Seagate Technology, a maker of hard-disk drives, jumped $1.52 to $32.91 after predicting revenue for its fiscal second quarter that topped Wall Street expectations late Tuesday.


— Bank of America fell 29 cents to $11.69 after Credit Suisse analysts lowered their outlook on the lender to "neutral" for "outperform," saying the current stock price overestimates the improvement in cost reduction that the bank can achieve this year.


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Private Manning of WikiLeaks Case Must Face Charges


Mark Wilson/Getty Images


Pfc. Bradley Manning, a former Army intelligence analyst, on Tuesday. His court-martial is scheduled to begin on March 6.







FORT MEADE, Md. — A military judge on Tuesday declined to dismiss charges against Pfc. Bradley E. Manning, a former Army intelligence analyst accused of providing archives of military and diplomatic documents to the antisecrecy group WikiLeaks, despite complaints by his defense team that he had been mistreated while being held at the Marines’ brig at Quantico, Va.




But the judge, Col. Denise Lind, ruled that brig officials had improperly kept Private Manning on stricter conditions, including procedures designed to prevent potentially suicidal detainees from injuring themselves, for excessive periods. As a remedy, she granted Private Manning 112 days of credit against any eventual prison sentence.


That amounted to little more than a symbolic victory for Private Manning, whose supporters had rallied around claims that he had been tortured at Quantico. Prosecutors are pursuing charges, including aiding the enemy and violating the Espionage Act, that could result in a life sentence if he is convicted. His court-martial is scheduled to begin on March 6.


The ruling by Colonel Lind came after a long pretrial hearing last month that amounted to a miniature trial over whether military officials had subjected Private Manning to unlawfully harsh conditions over the roughly eight months he spent at Quantico in 2010 and 2011. His defense team had asked for the charges to be dismissed or for 10-for-1 credit for time served for the bulk of his time in Quantico, which could have shaved around seven years from any eventual prison term.


But Colonel Lind, who spent nearly two hours reading her opinion in a small courtroom on Tuesday afternoon, found for the government on most of the disputed facts. She recounted in great detail Private Manning’s sometimes erratic behavior and mental problems both before and after his arrest in Iraq in 2010, including suicidal gestures and comments that she said made his captors legitimately fear that he was dwelling on suicide and biding his time until an opportunity arose.


“There was no intent to punish the accused by anyone in the Marine Corps brig staff or chain of command,” she said. “The intent was to make sure the accused was safe, did not hurt himself and was available for the trial.”


Still, Colonel Lind found that some steps brig officials had taken were excessive. The government had already conceded that Private Manning should not have been kept on the strictest status, “suicide risk,” on two occasions totaling seven days, after a brig medical official said that status was no longer necessary. She agreed, awarding one day of credit for each of those days.


She also said that it eventually became excessive and effectively punitive for brig officials to keep him on “prevention of injury” status — a category that did not require a doctor’s assent — for a 75-day period starting in November 2010, when his behavior had been stable for a lengthy period, and ending when he had an anxiety attack.


And she also awarded 20 days’ credit for a period beginning in April 2011 until he was transferred from Quantico later that month, when brig officials kept him on an extra-strict version of “prevention of injury” status. That included removing his underwear nightly after a comment he had laughingly made to a guard in early March that he could kill himself with its elastic band if he wanted.


Finally, she awarded him 10 days’ credit for a period in which brig officials allowed him just 20 minutes of exercise a day instead of the full hour other prisoners were granted.


Colonel Lind’s opinion also at one point discussed events reported in two articles in The New York Times in March 2011, recounting the removal of Private Manning’s clothing at night: a reaction, it is now clear, to his comment about killing himself with his underwear.


The first article said Private Manning had stood naked during inspection one morning in early March and cited his lawyer, David E. Coombs, as saying his client had been “forced” to do so. But Judge Lind portrayed the event as more ambiguous than an order: Private Manning, lacking clothes, had covered himself with a blanket, and a guard asked if that was how he stood at attention. He reacted by dropping the blanket.


The second article, published the next day, cited a Marine brig spokesman as saying that Private Manning would be required to stand outside his cell under similar conditions each morning. But starting the next day, she found, guards began giving Private Manning his clothing back each morning before inspection, and she said there was no evidence he had stood outside his cell rather than inside it.


Also on Tuesday, the judge began hearing arguments on a pair of motions by prosecutors seeking to restrict the ability of Private Manning’s defense team to call witnesses and introduce other testimony related to his motivation and whether the documents were overclassified.


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Why bother with a Facebook phone? Facebook’s app is already on 86% of iPhones and iPads






Rumors suggesting Facebook (FB) is working on a smartphone have resurfaced a number of times over the past year. Each time, Facebook denied the various claims. Facebook may indeed still be working on its own phone but as a new report from market research firm NPD Group shows, it probably doesn’t need to.


[More from BGR: Is Samsung the new Apple?]






Facebook makes money by gathering information about its users and serving targeted ads based on that data. Allowing users to update Facebook with fresh data as often as possible is obviously beneficial to the company, and smartphones present a terrific opportunity to give users access to their Facebook accounts from anywhere. The more people using Facebook’s mobile apps, the better, and Facebook’s smartphone penetration is absolutely staggering right now.


[More from BGR: iPhone 5 now available with unlimited service, no contract on Walmart’s $ 45 Straight Talk plan]


According to data published by NPD Group on Tuesday, Facebook’s iOS application was used by 86% of iPhone, iPad and iPod touch owners as of November 2012. On the Android platform, 70% of smartphone and tablet owners used Facebook’s mobile app in November.


No other third-party app even comes close to approaching Facebook’s mobile penetration. Google’s (GOOG) YouTube app is the next most popular third-party app on iOS with 40% penetration and Amazon’s (AMZN) mobile application is the second most popular third-party Android app with just 28% penetration.


So why would Facebook bother making its own phone?


One answer — perhaps the obvious one — is that an own-brand smartphone with custom software would give Facebook access to far more personal data than it can reach using third-party applications. Considering Facebook’s track record with matters relating to privacy, however, users may be reluctant to buy a Facebook phone.


In any case, a Facebook phone certainly doesn’t seem like a necessity for the time being. Instead, focusing on ways to effectively monetize the hundreds of millions of users who interact with Facebook from a smartphone or tablet each month might be a wiser use of resources.


This article was originally published on BGR.com


Social Media News Headlines – Yahoo! News




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Alison Sweeney Blogs: 'Oh, Dreaded Week Two' on The Biggest Loser






Only on People.com








01/08/2013 at 12:00 PM EST



Oh, dreaded week two! Emotions run high and numbers are typically low at the second weigh-in on The Biggest Loser. Never ones to keep things the same from season to season, it seemed like the prefect time to introduce the outdoor gyms created by each of the trainers.

Dolvett's dungeon pushed his team, but nothing compared to Jillian's gym ... or to Jillian's frustration with her team. As I watched the workout, I felt for Danni and Pam. Jillian's tenacity and relentlessness was hard to watch. I thought their conversation the next day was really important – and not just for each of them as individuals but for the audience, as well, to help us understand why Jillian fights so hard for, and how to not give up when the going gets tough.

I personally also love NFL week because of the incredible athletes that motivate our contestants. This season, eight-time NFL Pro Bowler Antonio Gates didn't disappoint. The best part of the challenge was the kids being reunited with their teams and how encouraging everyone was with each other. I loved every aspect of the challenge – I thought it did equalize everything, giving each team a chance at the prize. And yet the white team has now won back-to-back challenges!

It was so fun to see Bob teasing Gina. "This is not the Biggest Loser Resort & Spa!" he told her. He cracks me up! And WOW, what a change from Jillian in the last chance work out with Pam! I was so impressed! She had the conversation with them, followed through on her end of the bargain, and so did Pam. When Jill told me about it at the weigh-in I was shocked, but to watch it in the context of the show ... I was moved.

Those kid statistics in the Biggest Loser Fitness test are so important. As Dolvett said, "We are responsible. We have to do something." It's such a great idea to get kids motivated and taking those first steps. Remember that test – it definitely comes back into play later in the season!

The hardest part for all of us was in losing Nate. He and TC were both such strong influences in the house and worked so hard. They deserved every second on the Ranch and so much more time. But the changes Jillian made with them in a short time will hopefully last a long and healthy lifetime.

Favorite moment of the week: when Jillian was confronting Pam and she accidentally (Freudian slip?) said "bear claw" instead of "bear CRAWL." I loved the way it broke the tension, the way they both took a moment and laughed about it. I would never admit to Jill I know the name of any donut. Lol! It was a great moment.

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